Digenic inheritance of severe insulin resistance in a human pedigree

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

David R. Matthews, J P Hosker, A. Rudenski et al. · Diabetologia · 1985 · 31.4K citations · Full text

Medicine, Endocrinology, Physiology +17

Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension

Inês Barroso, Mark Gurnell, Vivion Crowley et al. · Nature · 1999 · 1.4K citations

Life Sciences, Genetics, Molecular Genetics +12

PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance

Naoto Kubota, Yasuo Terauchi, Hiroshi Miki et al. · Molecular Cell · 1999 · 1.4K citations · Full text

Life Sciences, Biochemistry, Physiology +12

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

E. Dale Abel, Odile D. Peroni, Jason K. Kim et al. · Nature · 2001 · 1.3K citations

Life Sciences, Endocrinology, Molecular Biology +14

Whole genome amplification from a single cell: implications for genetic analysis.

Lin Zhang, Xiufang Cui, Karin Schmitt et al. · Proceedings of the National Academy of Sciences · 1992 · 902 citations

Life Sciences, Genetics, Molecular Genetics +13