Concepedia

A Randomized, Double-Blind, Controlled Withdrawal Trial in Crohn’s Disease Patients in Long-term Remission on Azathioprine

Marc Lémann, Jean–Yves Mary, Jean‐Frédéric Colombel, Bernard Duclos, Jean–Claude Soulé, Éric Lerebours, R Modigliani, Yoram Bouhnik

Gastroenterology · 2005 · 351 citations · 33 references

Open access

Concepts

MedicineClinical SciencesPharmacotherapyGastroenterologyCrohn Disease PharmacotherapyInflammatory Bowel DiseaseInflammatory Bowel Disease CareInflammatory Disease PharmacotherapyAzathioprine UseClinical RemissionInflammatory Bowel Disease PathophysiologyInflammatory Bowel Disease TherapyLong-term Remission MaintenanceThiopurine TherapyWithdrawal Of Trial Participants

References

33

Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples

Richard Peto, M. C. Pike, P. Armitage et al. · British Journal of Cancer · 1977 · 8.4K citations · Full text

Public Health, Biostatistics, Clinical Medicine +13

Treatment of Crohn's Disease with 6-Mercaptopurine

Daniel H. Present, Burton I. Korelitz, Nathaniel Wisch et al. · New England Journal of Medicine · 1980 · 1K citations

Pharmacy, Pharmacology, Pharmacotherapy +13

“Proving the null hypothesis” in clinical trials

William C. Blackwelder · Controlled Clinical Trials · 1982 · 899 citations

Natural Sciences, Biostatistics, Experimental Design +10

Development and validation of an endoscopic index of the severity for Crohn's disease: a prospective multicentre study. Groupe d'Etudes Thérapeutiques des Affections Inflammatoires du Tube Digestif (GETAID).

J Y Mary, R Modigliani · Gut · 1989 · 881 citations · Full text

Medicine, Clinical Sciences, Internal Medicine +17

Low-Molecular-Weight Heparin in the Treatment of Patients with Venous Thromboembolism

The Columbus Investigators · New England Journal of Medicine · 1997 · 789 citations · Full text

Medicine, Hematology, Pharmacotherapy +12