Concepedia

A Randomized, Controlled Study to Investigate the Analgesic Efficacy of Single Doses of the Cannabinoid Receptor-2 Agonist GW842166, Ibuprofen or Placebo in Patients With Acute Pain Following Third Molar Tooth Extraction

Thor Ostenfeld, Jeffrey Price, Massimo Albanese, Jonathan Bullman, F. Guillard, Ingo Meyer, Rachel Leeson, Cristina Costantin, Luigi Ziviani, Pier Francesco Nocini,

Clinical Journal of Pain · 2011 · 122 citations · 35 references

DOI

Abstract

In comparison to ibuprofen, single doses of GW842166 (100 and 800 mg) failed to demonstrate clinically meaningful analgesia in the setting of acute dental pain.

References

35

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Activation of CB <sub>2</sub> cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS

Mohab Ibrahim, Hongfeng Deng, A. M. Zvonok et al. · Proceedings of the National Academy of Sciences · 2003 · 484 citations · Full text

Agonist‐inverse agonist characterization at CB<sub>1</sub> and CB<sub>2</sub> cannabinoid receptors of L759633, L759656 and AM630

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Philip T. Malan, Mohab Ibrahim, Hongfeng Deng et al. · Pain · 2001 · 389 citations

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CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain

Nick M. Clayton, Fiona H. Marshall, C. Bountra et al. · Pain · 2002 · 238 citations