Preparation of highly enantiopure stereoisomers of 1-(2,6-dimethylphenoxy)-2-aminopropane (mexiletine)

Elucidation of the absolute configurations of amino acids and amines by the modified mosher's method

Takenori Kusumi, Toshiro Fukushima, Ikuko I. Ohtani et al. · Tetrahedron Letters · 1991 · 129 citations

Life Sciences, Biochemistry, Medicinal Chemistry +7

On the Use of O-Methylmandelic Acid for the Establishment of Absolute Configuration of .alpha.-Chiral Primary Amines

Barry M. Trost, Richard C. Bunt, Shon R. Pulley · The Journal of Organic Chemistry · 1994 · 99 citations

Natural Sciences, Chemistry, Medicinal Chemistry +9

Resolution and Electrophysiological Effects of Mexiletine Enantiomers

Jacques Turgeon, Andrew C. G. Uprichard, P M Bélanger et al. · Journal of Pharmacy and Pharmacology · 1991 · 60 citations

Medicine, Cardiology, Pharmacology +17

Synthesis of new stable aliphatic isothiocyanate-based chiral derivatizing agent and application to indirect separation of chiral amino and thiol compounds

Oliver P. Kleidernigg, Wolfgang Lindner · Chromatographia · 1997 · 34 citations

Natural Sciences, Chemistry, Pharmaceutical Analysis +12

Stereospecific synthesis and absolute configuration of mexiletine

Carlo Franchini, Carla Cellucci, Filomena Corbo et al. · Chirality · 1994 · 33 citations

Pharmacy, Chemistry, Medicinal Chemistry +13