Antimicrobial Agents and Chemotherapy · 2011 · 210 citations · 20 references
Life SciencesGeneticsMicrobiologyBacteriologyGenomicsMicrobial GeneticsAntibiotic ResistanceAntibiotic Resistance GeneticsBacterial GeneticsBacterial PathogenesisCarbapenem ResistanceHorizontal Gene TransferAcinetobacter Baumannii InfectionAcinetobacter Baumannii ResistanceBeta-lactamase Gene TransferCarbapenem Resistance MechanismsCarbapenem Resistance PlasmidsOxacillinase CarbapenemasesResistance Gene DisseminationTransposon-mediated Resistance
A multidrug-resistant Acinetobacter baumannii isolate recovered from a patient hospitalized in Switzerland after a transfer from Serbia produced the NDM-1 carbapenemase. The bla(NDM-1) gene was part of a chromosomally located Tn125 composite transposon bracketed by two copies of the same insertion sequence, ISAba125. This transposon was also associated with the acquisition and expression of the bla(NDM-2) gene in an A. baumannii isolate in Germany. Tn125 appears to be the main vehicle for dissemination of bla(NDM) genes in that species.
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Kanimozhi Kumarasamy, Mark A. Toleman, Timothy R. Walsh et al. · The Lancet Infectious Diseases · 2010 · 2.9K citations · Full text
Multiple Antimicrobial Resistance in Plague: An Emerging Public Health Risk
Timothy J. Welch, W. Florian Fricke, Patrick F. McDermott et al. · PLoS ONE · 2007 · 400 citations · Full text