Differential contribution of C-terminal regions of dermorphin and dermenkephalin to opioid-sites selection and binding potency

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

W R Martin, C. G. Eades, JP Thompson et al. · Journal of Pharmacology and Experimental Therapeutics · 1976 · 3K citations

Medicine, Pharmacology, Veterinary Pharmacology +16

Endogenous opioid peptides: multiple agonists and receptors

John A.H. Lord, Angela A. Waterfield, John Hughes et al. · Nature · 1977 · 2.5K citations

Medicine, Pharmacology, Neuroendocrinology +9

Multiple opiate receptors. Enkephalins and morphine bind to receptors of different specificity.

K J Chang, Pedro Cuatrecasas · Journal of Biological Chemistry · 1979 · 684 citations · Full text

Medicine, Pharmacology, Neuropharmacology +11

Analogues of β-LPH61–64 posessing selective agonist activity at μ-opiate receptors

B.K. Handa, Anthony C. Lane, John A.H. Lord et al. · European Journal of Pharmacology · 1981 · 507 citations

Pharmacy, Medicinal Chemistry, Pharmacology +13