Concepedia

Protection of Epithelial Barrier Function by the Crohn's Disease Associated Gene Protein Tyrosine Phosphatase N2

Michael Scharl, Gisela Paul, Achim Weber, Barbara Jung, Michael J. Docherty, Martin Hausmann, Gerhard Rogler, Kim E. Barrett, Declan F. McCole

Gastroenterology · 2009 · 117 citations · 37 references

DOIFull text

Open access

Concepts

References

37

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

Panos Deloukas, Audrey Duncanson, Dominic Kwiatkowski et al. · Nature · 2007 · 9.6K citations · Full text

, , +12

Stat3 as an Oncogene

Jacqueline Bromberg, Melissa H Wrzeszczynska, Geeta Devgan et al. · Cell · 1999 · 2.8K citations · Full text

, , +8

Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn’s disease LP cells manifest increased secretion of IFN-γ, whereas ulcerative colitis LP cells manifest increased secretion of IL-5

Ivan J. Fuss, Markus F. Neurath, Monica Boirivant et al. · The Journal of Immunology · 1996 · 1.2K citations · Full text

, , +17

Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease

Natalie Bürgel, Dorothee Günzel, J Richter et al. · Gut · 2006 · 1.2K citations · Full text

, , +16

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

Miles Parkes, Jeffrey C. Barrett, Natalie J. Prescott et al. · Nature Genetics · 2007 · 1.2K citations · Full text

, , +15