Some anabolic aspects of protein metabolism in riboflavin deficiency in the rat

Abstract

Flavin nucleotides are components of certain enzyme systems which are involved in the oxidation of nitrogenous compounds, including at least some of the amino acids. The oldest and best-known evidence for this relationship was derived from studies of biochemical systems in vitro, but it is also supported by the results of studies on intact animals. For example, Burch, Lowry, Padilla & Combs (1956) showed that when rats were deprived of riboflavin for 6 weeks the activities of xanthine oxidase and of several amino-acid oxidases in their livers were substantially reduced.