Internal Medicine · 2007 · 34 citations · 17 references
VasculitisImmunologyPathologyImmune SystemCirrhosisImmune DysregulationViral HepatitisAutoantigensAutoantibodiesNeuroimmunologyRheumatoid ArthritisRheumatologyAutoimmune DiseaseSystemic SclerodermaAutoimmunityImmunologic DiseaseChronic Viral InfectionSclerodermaHepatologyHepatitis CSjögren’s SyndromeConsensus InterferonHepatitisSystemic SclerosisAntiviral TherapyMedicine
A 66-year-old woman developed systemic sclerosis (SSc) after receiving interferon alphacon-1 (IFNalphacon-1; consensus interferon) therapy for chronic hepatitis C. She suffered from Raynauds phenomenon about 1 year after a course of IFNalphacon-1 therapy. The combination of proximal scleroderma, Raynauds phenomenon, and ANA positivity led to a diagnosis of systemic sclerosis (SSc). IFN has multiple effects on the immune system and is known to trigger the development of autoantibodies, as well as the onset or exacerbation of autoimmune disease. We suspect that the immunomodulatory effects of IFNalphacon-1 triggered the clinical manifestations of SSc in this patient. To our knowledge this is only the third case of SSc after IFNalpha therapy, and it is the first case associated with IFNalphacon-1 therapy.
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Anita B. Roberts, Michael B. Sporn, Richard K. Assoian et al. · Proceedings of the National Academy of Sciences · 1986 · 2.9K citations · Full text
Side effects of high-dose interferon therapy for chronic hepatitis C
T Okanoue, Shinichi Sakamoto, Yoshito Itoh et al. · Journal of Hepatology · 1996 · 463 citations