Concepedia

Selection and fading of resistance mutations in women and infants receiving nevirapine to prevent HIV-1 vertical transmission (HIVNET 012)

Susan H. Eshleman, Martin Mracna, Laura Guay, Martina Deseyve, Shawn Cunningham, Mark Mirochnick, Philippa Musoke, Thomas R. Fleming, Mary Glenn Fowler, Lynne Mofenson,

AIDS · 2001 · 420 citations · 7 references

DOI

Abstract

NVP(R) was detected more frequently in infants than women following NVP prophylaxis, and different patterns of NVP(R) mutations were detected in women versus infants. NVP(R) was detected infrequently in infants with late HIV-1 infection. NVP-resistant HIV-1 faded from detection in women and infants over time.

References

7

Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial

Laura Guay, Philippa Musoke, Thomas R. Fleming et al. · The Lancet · 1999 · 1.6K citations

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Nevirapine resistance mutations of human immunodeficiency virus type 1 selected during therapy

Douglas D. Richman, Diane V. Havlir, Jacques Corbeil et al. · Journal of Virology · 1994 · 578 citations · Full text

, , +13

A phase I/II study of the safety and pharmacokinetics of nevirapine in HIV-1-infected pregnant Ugandan women and their neonates (HIVNET 006)

Philippa Musoke, Laura Guay, Danstan Bagenda et al. · AIDS · 1999 · 215 citations

Identification of the K103N resistance mutation in Ugandan women receiving nevirapine to prevent HIV-1 vertical transmission

J. Brooks Jackson, Graziella Becker‐Pergola, Laura Guay et al. · AIDS · 2000 · 212 citations

Pharmacokinetics of Nevirapine in Human Immunodeficiency Virus Type 1-Infected Pregnant Women and Their Neonates

Mark Mirochnick, Terry Fenton, Paul Gagnier et al. · The Journal of Infectious Diseases · 1998 · 196 citations · Full text