Concepedia

Role of <i>pncA</i> and <i>rpsA</i> Gene Sequencing in Detection of Pyrazinamide Resistance in Mycobacterium tuberculosis Isolates from Southern China

Yaoju Tan, Zuqiong Hu, Tianyu Zhang, Xingshan Cai, Haobin Kuang, Junyu Chen, Feng Yang, Ke Zhang, Shouyong Tan, Yanlin Zhao

Journal of Clinical Microbiology · 2013 · 92 citations · 31 references

DOIFull text

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Concepts

Abstract

We sequenced pncA and rpsA genes plus flanking regions of 161 Mycobacterium tuberculosis isolates and found 10 new pncA and 3 novel rpsA mutations in pyrazinamide-resistant strains determined by the Bactec MGIT 960 system. The 3' end of rpsA might be added as the target of molecular detection of pyrazinamide susceptibility.

References

31

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