Science · 1992 · 392 citations · 36 references
Life SciencesHuman DevelopmentPhysiologyChild DevelopmentDevelopmental PhysiologyDevelopmental PsychologyChild GrowthGrowth And DevelopmentGrowth AssessmentGrowth DynamicsInfant GrowthPostnatal DevelopmentDevelopmental Growth PhysiologyLongitudinal Growth AnalysisLongitudinal Growth PatternsPostnatal Growth PatternsPostnatal Growth Trajectories
Human growth has been viewed as a continuous process characterized by changing velocity with age. Serial length measurements of normal infants were assessed weekly (n = 10), semiweekly (n = 18), and daily (n = 3) (19 females and 12 males) during their first 21 months. Data show that growth in length occurs by discontinuous, aperiodic saltatory spurts. These bursts were 0.5 to 2.5 centimeters in amplitude during intervals separated by no measurable growth (2 to 63 days duration). These data suggest that 90 to 95 percent of normal development during infancy is growth-free and length accretion is a distinctly saltatory process of incremental bursts punctuating background stasis.
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The E2F transcription factor is a cellular target for the RB protein
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A novel cyclin encoded by a bcl1-linked candidate oncogene
Toru Motokura, Theodora Bloom, Hyung Goo Kim et al. · Nature · 1991 · 1.3K citations