Cu(i)-catalyzed tandem decarboxylative/C–H activation coupling of cyclic diketones, proline and alkynes: synthesis of α-alkynylated pyrrolidine-oxyindoles

Abstract

An efficient ligand/base and oxidant-free copper(I) catalyzed intermolecular direct alkynylation (IDA) strategy has been developed for the synthesis of α-alkynylated pyrrolidine-oxindole derivatives using cyclic diketones, amino acids and alkynes via tandem decarboxylative/C–H activation and reductive-amination strategy.