Demonstration of an enzyme variant in a case of congenital methaemoglobinaemia.

Abstract

The experiments reported in this paper, conducted over a period of nine weeks, indicate that different electrophoretic fractions of yG-globulin possess different breakdown rates; the observed half-life of the entire yG-globulin preparation being a mean of the individual values. The overall breakdown rate is non-linear and the half-life values increase with time. However, mean half-life values measured over the nine-week period were 25 days (J. W.) and 18 days (patient) respectively. These half-life values are in good agreement with those of Cohen and Freeman (1960), who reported half-life values of 21-26 days for yG-globulins in the normal individual.