Drug Development and Industrial Pharmacy · 1993 · 26 citations · 35 references
PharmacyPharmaceuticsPharmacologyBioavailabilityDrug DeliveryOral Drug DeliveryDrug Delivery BiomaterialsNasal Drug DeliveryNasal FormulationsNasal PhysiologyRoute Of AdministrationRoutes Of Drug AdministrationBioadhesive HydrogelsHepatic First-pass EffectIntranasal AdministrationIntranasal FormulationsMicrosphere Nasal FormulationsNasal AdministrationNasal PharmacokineticsSystemic Administration
By its anatomy and physiology, due to the great amount of air treated there, the nasal route represents a very interesting possibility for the administration of products degraded in the gastro-intestinal tract or inhibited by the first hepatic pass. The nasal dosage forms most studied are bioadhesive hydrogels and microspheres, especially for the systemic administration of peptides.
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Powder dosage form of insulin for nasal administration
Tsuneji Nagai, Nishimoto Yuji, Naoki Nambu et al. · Journal of Controlled Release · 1984 · 168 citations