Tilorone-induced lysosomal storage of sulphated glycosaminoglycans can be separated from tilorone-induced enhancement of lysosomal enzyme secretion

Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.

S Ohkuma, Brian D. Poole · Proceedings of the National Academy of Sciences · 1978 · 2.2K citations · Full text

Cellular Physiology, Proton Trapping, Normal Ph +19

Lysosomes in biology and pathology

Food and Cosmetics Toxicology · 1977 · 2K citations

Cell Pathology, Lysosomal Storage Disease, Natural Sciences +10

Biosynthesis of lysosomal enzymes in fibroblasts. Synthesis as precursors of higher molecular weight.

Andrej Hasilík, Elizabeth F. Neufeld · Journal of Biological Chemistry · 1980 · 805 citations · Full text

Biosynthesis, Higher Molecular Weight, Cellular Enzymology +7

Lysosomes and storage diseases

H G Hers, François Van Hoof · 1973 · 744 citations

Lysosomal Storage Disease, Pathogenesis, Autophagy +10

Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling.

Alfonso González‐Noriega, Jeffrey H. Grubb, Venugopal D. Talkad et al. · The Journal of Cell Biology · 1980 · 741 citations · Full text

Bioorganic Chemistry, Molecular Biology, Enzymatic Modification +19