Biological Activity of 6-Pentyl-2<i>H</i>-pyran-2-one and Its Analogs

Abstract

The in vitro biological activities (antifungal, phytotoxic) for a group of fungal metabolites structurally related to 6-pentyl-2H-pyran-2-one have been determined. Six compounds were tested and showed a degree of phytotoxicity in one or more of the assays employed. From among the analogs tested, (R)-5,6-dihydro-6-pentyl-2H-pyran-2-one has been identified as the most active against Penicillium species. Keywords: Antifungal; phytotoxic; 6-alkyl-2H-pyran-2-one; 5-alkyl-2H-furan-2-one