Rolling Circle Amplification‐Based DNA Origami Nanostructrures for Intracellular Delivery of Immunostimulatory Drugs

Abstract

Several single-stranded scaffold DNA, obtained from rolling circle amplification (RCA), are folded by different staples to form DNA nanoribbons. These DNA nanoribbons are rigid, simple to design, and cost-effective drug carriers, which are readily internalized by mammalian cells and show enhanced immunostimulatory activity.