Nano Letters · 2003 · 627 citations · 17 references
EngineeringBioengineeringMaterials ScienceBiosensorsNanobiotechnologyNanomaterialsDna BiosensorsElectrochemical BiosensorsElectrochemical DetectionElectrochemical SensorsNanotubesNucleic Acid BiosensorsDna Hybridization DetectionDna NanobiosensorsElectrochemical Dna BiosensorsElectrochemical NanobiosensorsElectrochemical NanosensorsElectrochemical Nucleic Acid BiosensorsMulti-walled Carbon NanotubesUltrasensitive Detection
A nanoelectrode array based on vertically aligned multiwalled carbon nanotubes (MWNTs) embedded in SiO 2 is used for ultrasensitive DNA detection. Characteristic electrochemical behaviors are observed for measuring bulk and surface-immobilized redox species. Sensitivity is dramatically improved by lowering the nanotube density. Oligonucleotide probes are selectively functionalized to the open ends of nanotubes. The hybridization of subattomole DNA targets can be detected by combining such electrodes with Ru(bpy) 3 2+ mediated guanine oxidation.
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Allen J. Bard, H. W. Salzberg · Journal of The Electrochemical Society · 1969 · 634 citations