Synthetic Communications · 2014 · 14 citations · 11 references
Natural SciencesChemistryCatalysisInorganic ChemistryOrganic ChemistryCross-coupling ReactionsHalogen ChemistryHeterocycle SynthesisHeterocyclic ChemistryMetal CatalysisOrganic SynthesisAlkylation ReactionsCross-coupling CatalysisCross-electrophile CouplingNickel CatalysisNickel-catalyzed Cross-couplingPyridine ChemistryPyridine SynthesisReductive Cross-coupling
Abstract This article highlights Ni-catalyzed cross-electrophile coupling of halogenated pyridines with secondary alkyl bromides using zinc as the terminal reductant. With this protocol, we have successfully achieved different alkyl-substituted pyridines in moderate to excellent yields.
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