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Iron-Catalyzed Chemoselective Cross-Coupling of Primary and Secondary Alkyl Halides with Arylzinc Reagents
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2005
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Chemical EngineeringArylzinc ReagentsSecondary Alkyl HalidesEngineeringBiochemistryIron CatalysisMagnesium SaltFunctional-group-compatible Cross-coupling ReactionNatural SciencesAlkene MetathesisOrganic ChemistryCross-coupling ReactionOrganometallic CatalysisCatalysisIron-catalyzed Chemoselective Cross-couplingChemistryHeterocycle ChemistryAsymmetric Catalysis
Functional-group-compatible cross-coupling reaction of alkyl halides with arylzinc reagents takes place under iron catalysis in the presence of TMEDA, producing a variety of aromatic compounds in good to excellent yield. The pronounced effect of a magnesium salt was found to be the key to the promotion of the iron-catalyzed coupling reaction.