Communications in Statistics - Simulation and Computation · 1998 · 20 citations · 12 references
Natural SciencesBiophysicsMathematicsIon Channel BiophysicsStatistical ModelingStatisticsComputational StatisticsInferential StatisticsMathematical BiologyMembrane ElectrophysiologyMoment AnalysisProbability DistributionsGamma Distribution ModelsGeneralized Gamma ModelMoment RatiosSample Size CalculationSample Size EstimationSingle-channel Current Fluctuations
Abstract The distribution of the ratio of independent gamma variates x and y each with shape parameters unity is studied, the ratio being t=x/(x+y). The problem arises from a model of ionic current fluctuations in biological membranes. Moments of the distribution are found, and an algorithm relating the fundamental parameter to the mean. This is used to set up percentage points. The moment estimator of the fundamental ratio parameter is defined as a series using Faà di Bruno's formulas for derivatives of a composite function (function of a function). Terms to order four in the sample size are given for mean and variance and compared to assessment using Pearson-Tukey transformations. Keywords: AlgorithmFaà di Brunogamma distributioninverse seriesmonotonicitypercentage pointsratio of gamma variatessimulation
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Ionic channels of excitable membranes
General Pharmacology The Vascular System · 1985 · 7K citations
The Ionic Channels in Excitable Membranes
R. D. Keynes · Novartis Foundation symposium · 1975 · 1.7K citations