Concepedia

A mechanism underlying compound-induced voltage shift in the current activation of hERG by antiarrhythmic agents

Kazuharu Furutani, Yuko Yamakawa, Atsushi Inanobe, Miki Iwata, Yuko Ohno, Yoshihisa Kurachi

Biochemical and Biophysical Research Communications · 2011 · 17 citations · 23 references

DOI

Concepts

References

23

A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel

Michael C. Sanguinetti, Changan Jiang, Mark Curran et al. · Cell · 1995 · 2.4K citations · Full text

, , +16

Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents.

Michael C. Sanguinetti, Nancy K. Jurkiewicz · The Journal of General Physiology · 1990 · 1.5K citations · Full text

, , +17

HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

Matthew C. Trudeau, Jeffrey W. Warmke, Barry Ganetzky et al. · Science · 1995 · 1.2K citations

, , +17

Clinical efficacy of amiodarone as an antiarrhythmic agent

Mauricio B. Rosenbaum, Pablo A. Chiale, M.Susana Halpern et al. · The American Journal of Cardiology · 1976 · 573 citations

, , +14

New insights about HERG blockade obtained from protein modeling, potential energy mapping, and docking studies

Ramy Farid, Tyler Day, Richard A. Friesner et al. · Bioorganic & Medicinal Chemistry · 2006 · 504 citations

, , +17