Concepedia

AMP-Activated Protein Kinase Deficiency Enhances Myocardial Ischemia/Reperfusion Injury but Has Minimal Effect on the Antioxidant/Antinitrative Protection of Adiponectin

Yajing Wang, Erhe Gao, Ling Tao, Wayne Bond Lau, Yuexin Yuan, Barry J. Goldstein, Bernard L. Lopez, Theodore A. Christopher, Rong Tian, Walter J. Koch,

Circulation · 2009 · 135 citations · 27 references

DOIFull text

Open access

Abstract

Collectively, our results demonstrated that AMPK deficiency significantly increases MI/R injury in vivo but has minimal effect on the antioxidative/antinitrative protection of adiponectin.

References

27

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

Toshimasa Yamauchi, Junji Kamon, Yasuhiko Minokoshi et al. · Nature Medicine · 2002 · 4.2K citations

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Adiponectin Stimulates Production of Nitric Oxide in Vascular Endothelial Cells

Hui Chen, Monica Montagnani, Tohru Funahashi et al. · Journal of Biological Chemistry · 2003 · 984 citations · Full text

Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2–dependent mechanisms

Rei Shibata, Kaori Sato, David R. Pimentel et al. · Nature Medicine · 2005 · 973 citations · Full text

, , +11

Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl–CoA carboxylase inhibition and AMP-activated protein kinase activation

Eva Tomás, Tsu‐Shuen Tsao, Asish K. Saha et al. · Proceedings of the National Academy of Sciences · 2002 · 966 citations · Full text

, , +21

Adiponectin Stimulates Angiogenesis by Promoting Cross-talk between AMP-activated Protein Kinase and Akt Signaling in Endothelial Cells

Noriyuki Ouchi, Hideki Kobayashi, Shinji Kihara et al. · Journal of Biological Chemistry · 2004 · 751 citations · Full text