Regioselective synthesis of inhibitors of histone acetyl transferase covalently linking spermidine to the s-terminus of coenzyme a and fragments.

Structure of chloramphenicol acetyltransferase at 1.75-A resolution.

Andrew G. W. Leslie, P.C.E. Moody, William V. Shaw · Proceedings of the National Academy of Sciences · 1988 · 169 citations · Full text

Life Sciences, Biochemistry, Microbiology +17

New chemistry of naturally occurring polyamines

Bruce Ganem · Accounts of Chemical Research · 1982 · 128 citations

Natural Sciences, Chemistry, Bioisosterism +6

Conditions for the self-catalysed inactivation of carnitine acetyltransferase. A novel form of enzyme inhibition

J. F. A. Chase, Philip K. Tubbs · Biochemical Journal · 1969 · 97 citations · Full text

Life Sciences, Biochemistry, Biocatalysis +12

Methods for the selective modification of spermidine and its homologs

Raymond J. Bergeron · Accounts of Chemical Research · 1986 · 74 citations

Pharmacy, Chemical Biology, Drug Discovery +5

Inhibition of histone acetylation by N-[2-(S-coenzyme A)acetyl] spermidine amide, a multisubstrate analog.

Paul M. Cullis, Richard Wolfenden, Lawrence S. Cousens et al. · Journal of Biological Chemistry · 1982 · 54 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +8