Concepedia

Combination Effects of Enalapril and Losartan on Lipid Peroxidation in the Kidneys of KK-A<sup>y</sup>/Ta Mice

Takahiko Yamazaki, Mitsuo Tanimoto, Tomohito Gohda, Ikko Ohara, Shinji Hagiwara, Maki Murakoshi, Masakazu Matsumoto, Shigeru Kaneko, Tatsuya Aoki, Hitoe Toyoda,

Nephron Experimental Nephrology · 2009 · 23 citations · 31 references

DOI

Abstract

It appears that enalapril and/or losartan, especially in combination, inhibited accumulation of CML/MDA/4-HNE in diabetic renal tissues. These effects might be related to lipid peroxidation via tissue-specific activation of adiponectin and AMPK.

References

31

Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38

UK Prospective Diabetes Study Group · BMJ · 1998 · 6.7K citations · Full text

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

Toshimasa Yamauchi, Junji Kamon, Yasuhiko Minokoshi et al. · Nature Medicine · 2002 · 4.2K citations

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Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients

Kikuko Hotta, Tohru Funahashi, Yukio Arita et al. · Arteriosclerosis Thrombosis and Vascular Biology · 2000 · 3.1K citations

Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. UK Prospective Diabetes Study Group.

Robert D. Turner, R Holman · 1998 · 2K citations

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Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial

Johannes F.E. Mann, Roland E. Schmieder, Matthew McQueen et al. · The Lancet · 2008 · 1.6K citations

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