Molecular variability of group 1 and 5 grass pollen allergens between Pooideae species: implications for immunotherapy

Abstract

Major pollen allergens from distinct grass species bear both shared and species-restricted T and B cell immune epitopes. When compared with single extracts, a five grass pollen extract is thus more suitable for specific immunotherapy, as it contains a broader repertoire of the IgE epitopes to which patients are sensitized.