Parg deficiency confers radio-sensitization through enhanced cell death in mouse ES cells exposed to various forms of ionizing radiation

Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor

Seong-Woon Yu, Hongmin Wang, Marc F. Poitras et al. · Science · 2002 · 1.8K citations

Life Sciences, Cell Biology, Molecular Biology +15

RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly

Michael S.Y. Huen, Robert A. Grant, Isaac A. Manke et al. · Cell · 2007 · 1K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality

David W. Koh, Ann M. Lawler, Marc F. Poitras et al. · Proceedings of the National Academy of Sciences · 2004 · 336 citations · Full text

Life Sciences, Developmental Biology, Molecular Biology +17

Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1.

Stephany Veuger, Nicola J. Curtin, Caroline J. Richardson et al. · PubMed · 2003 · 331 citations · Full text

Medicine, Oncology, Radiation Oncology +17

Role of ERas in promoting tumour-like properties in mouse embryonic stem cells

Kazutoshi Takahashi, Kaoru Mitsui, Shinya Yamanaka · Nature · 2003 · 329 citations

Medicine, Cancer Biology, Oncology +14