Repair of DNA Damage Induced by Accelerated Heavy Ions in Mammalian Cells Proficient and Deficient in the Non-homologous End-Joining Pathway

Ryuichi Okayasu, Maki Okada, Atsushi Okabe, +3

Radiation Research

Contributions of Direct and Indirect Actions in Cell Killing by High-LET Radiations

Ryoichi Hirayama, Atsushi Ito, Masanori Tomita, +8

Radiation Research

Cell KillingDna DamageRadiation EffectRadiation ExposureIndirect Actions +16

A deficiency in DNA repair and DNA-PKcs expression in the radiosensitive BALB/c mouse.

Ryuichi Okayasu, Katsutoshi Suetomi, Yongjia Yu, +4

PubMed

Gamma Ray-induced DsbsDna DamageGeneticsRadiation EffectRadiation Exposure +16

Elevated breast cancer risk in irradiated BALB/c mice associates with unique functional polymorphism of the Prkdc (DNA-dependent protein kinase catalytic subunit) gene.

Yongjia Yu, Ryuichi Okayasu, Michael M. Weil, +6

PubMed

Breast OncologyCancer PathologyCancer BiologyElevated SusceptibilityTumor Biology +15

Effects of Carbon Ion Beam on Putative Colon Cancer Stem Cells and Its Comparison with X-rays

Xing Cui, Kazuhiko Oonishi, Hirohiko Tsujii, +6

Cancer Research

Tumor BiologyRadiation TherapyMedicineRadiation EffectRadiation Exposure +10

Inhibition of homologous recombination repair in irradiated tumor cells pretreated with Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin

Miho Noguchi, Dong Yu, Ryoichi Hirayama, +5

Biochemical and Biophysical Research Communications

Tumor BiologyIrradiated Tumor CellsRadiation TherapyHsp90 InhibitorAnti-cancer Agent +7

Silencing expression of the catalytic subunit of DNA-dependent protein kinase by small interfering RNA sensitizes human cells for radiation-induced chromosome damage, cell killing, and mutation.

Yuanlin Peng, Qinming Zhang, Hatsumi Nagasawa, +3

PubMed

Radiation EffectRadiation ExposureMolecular BiologyDna-dependent Protein KinaseRadiation Biology +14

Roles of the Major, Small, Acid-Soluble Spore Proteins and Spore-Specific and Universal DNA Repair Mechanisms in Resistance of <i>Bacillus subtilis</i> Spores to Ionizing Radiation from X Rays and High-Energy Charged-Particle Bombardment

Ralf Moeller, Peter Setlow, G. Horneck, +6

Journal of Bacteriology

GeneticsRadiation EffectBacteriologyMolecular BiologyHigh-energy Charged-particle Bombardment +14

The complexity of DNA double strand breaks is a critical factor enhancing end-resection

Hirohiko Yajima, Hiroshi Fujisawa, Nakako Izumi Nakajima, +4

DNA repair

ChromatinGenome InstabilityDna DamageCritical FactorGenetics +10

Linear DNA Elution Dose Response Curves Obtained in CHO Cells with Non-unwinding Filter Elution after Appropriate Selection of the Lysis Conditions

Ryuichi Okayasu, George Iliakis

International Journal of Radiation Biology

Detergent TypeChromatinLysis ConditionsLysis TemperatureNucleic Acid Chemistry +13