Artificial Cells Blood Substitutes and Biotechnology · 1994 · 14 citations · 0 references
Natural SciencesBiochemistryBioengineeringBiomaterialsPolymer ChemistryProtein EngineeringHemoglobin PhysiologyPolymer FunctionalizationPolymeric BiomaterialsPolymerization ChemistryPolymerization ProcessesProtein-based BiomaterialsHemoglobin FunctionHemoglobin S PolymerizationHemoglobin Structure
By employing proprietary polymerization agents possessing specific binding groups and by completing diaspirin crosslinked hemoglobin (DCLHb) polymerization under specific conditions, we have selectively achieved the following objectives: (1) the P50 was adjusted to the physiologic range or left- or right-shifted; (2) the surface of DCLHb was modified ("decorated"); (3) DCLHb was polymerized but not decorated; (4) DCLHb was polymerized and decorated; or (5) DCLHb was site-specifically modified and polymerized.