Chemical Communications · 2009 · 106 citations · 16 references
PharmacyMedicinal ChemistryPharmacologyChemotherapyDrug DesignDrug DiscoveryCancer EpigeneticsChromatinDna ChemistryHistone ProteinsLigand BindingLigand-based DesignDna Binding SitesDna InteractionsDna-binding MotifsPlatinum CompoundsPlatinum-based Agents
The successful design and synthesis of a novel multifunctional platinum drug candidate with DNA binding, histone deacetylase inhibitory activity and enhanced selectivity for cancer cells are described.
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Crystal structure of the nucleosome core particle at 2.8 Å resolution
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