Concepedia

Mechanisms of resistance to N-[5-[N-(3, 4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl]-L-glutamic acid (ZD1694), a folate-based thymidylate synthase inhibitor, in the HCT-8 human ileocecal adenocarcinoma cell line

Kun Lu, Ming-biao Yin, John J. McGuire, Enzo Bonmassar, Y M Rustum

Biochemical Pharmacology · 1995 · 37 citations · 27 references

DOI

Concepts

References

27

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

John M. Chirgwin, Alan Przybyla, Raymond J. MacDonald et al. · Biochemistry · 1979 · 22.2K citations

, , +9

New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening

Philip Skehan, Ritsa Storeng, Dominic A. Scudiero et al. · JNCI Journal of the National Cancer Institute · 1990 · 9.8K citations

, , +10

Ribonucleic acid isolated by cesium chloride centrifugation

Vladimir Glišin, Radomir Crkvenjakov, Craig V. Byus · Biochemistry · 1974 · 2.2K citations

, , +8

Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase.

Edward Chu, David M. Koeller, John Casey et al. · Proceedings of the National Academy of Sciences · 1991 · 385 citations

, , +11

ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.

A.L. Jackman, G A Taylor, William Gibson et al. · PubMed · 1991 · 359 citations

, , +10