Organic & Biomolecular Chemistry · 2013 · 29 citations · 41 references
Natural SciencesChemistryOrganic ChemistryCross-coupling ReactionsHeterocycle SynthesisMacrocycle SynthesisRetrosynthetic AnalysisEnantioselective SynthesisHeterocycle FunctionalizationStereocontrolled Library SynthesisStereoselective SynthesisStereospecific Reaction Design
An efficient and expeditious DABCO-mediated synthesis of functionalized enamides from alkenes is delineated. The reaction proceeds through an unprecedented cascade involving an Aza-Michael addition/α-bromination/elimination and a Morita-Baylis-Hillman type reaction to generate functionalized enamides in a regio- & stereoselective fashion.
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The Atom Economy—A Search for Synthetic Efficiency
Copper-Catalyzed Coupling of Amides and Carbamates with Vinyl Halides
Lei Jiang, Gabriel E. Job, Artis Klapars et al. · Organic Letters · 2003 · 399 citations