From Genetic Diversity to Metabolic Unity: Studies on the Biosynthesis of Aurafurones and Aurafuron-like Structures in Myxobacteria and Streptomycetes

Basic local alignment search tool

Stephen F. Altschul, Warren Gish, Webb Miller et al. · Journal of Molecular Biology · 1990 · 92.8K citations

Bioinformatics, Engineering, Information Retrieval +10

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

Steffan N. Ho, Henry D. Hunt, Robert M. Horton et al. · Gene · 1989 · 7.5K citations

Natural Sciences, Genetics, Directed Evolution +6

A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of <i>Paederus</i> beetles

Jörn Piel · Proceedings of the National Academy of Sciences · 2002 · 601 citations · Full text

Biology, Biosynthesis, Marine Biotechnology +14

Evolutionary Implications of Bacterial Polyketide Synthases

Holger Jenke‐Kodama, Axel Sandmann, Rolf Müller et al. · Molecular Biology and Evolution · 2005 · 363 citations · Full text

Evolutionary Implications, Stepwise Biosynthesis, Biosynthesis +15

Conserved Amino Acid Residues Correlating With Ketoreductase Stereospecificity in Modular Polyketide Synthases

Patrick Caffrey · ChemBioChem · 2003 · 363 citations

Biosynthesis, Aldehyde Dehydrogenase, Biochemistry +14