A functional in vitro model of rat blood–brain barrier for molecular analysis of efflux transporters

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Alfred H. Schinkel, Jasper Smit, Olaf van Tellingen et al. · Cell · 1994 · 2.3K citations

Medicine, Pharmacokinetics, Pharmacology +14

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

Carlos Cordon‐Cardo, James P. O’Brien, D Casals et al. · Proceedings of the National Academy of Sciences · 1989 · 1.7K citations · Full text

Medicine, Oncology, Pharmacology +16

Blood‐brain barrier‐specific properties of a human adult brain endothelial cell line

Babette Weksler, Eva-Anne Subileau, Nicolas Perrière et al. · The FASEB Journal · 2005 · 1.3K citations

Life Sciences, Cell Biology, Cell Adhesion +12

A cell culture model of the blood-brain barrier.

Lee L. Rubin, Deborah E. Hall, Stephen Porter et al. · The Journal of Cell Biology · 1991 · 774 citations · Full text

Life Sciences, Cell Biology, Neuroscience +17

Growth and cultivation of dissociated neurons and glial cells from embryonic chick, rat and human brain in flask cultures.

J Booher, M. Sensenbrenner · PubMed · 1972 · 760 citations

Life Sciences, Developmental Biology, Neuroscience +15