Publication | Open Access
The Brain-Derived Neurotrophic Factor val66met Polymorphism and Variation in Human Cortical Morphology
892
Citations
22
References
2004
Year
NeuropsychologyBrain FunctionBrain DevelopmentGeneticsBdnf GeneHuman MemorySocial SciencesPsychiatric GeneticsNeurologyNeuropathologyCognitive NeuroscienceBrain MorphologyNeurogeneticsCognitive ScienceMolecular NeuroscienceHuman Cortical MorphologyBrain StructureNeuroimagingGenetic FactorImaging GenomicsNeuroimaging BiomarkersNeuroanatomyNeurobiological FactorNeuroscienceBiological PsychiatryMedicineBrain-derived Neurotrophic Factor
A variation in the BDNF gene (val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated with several neurological and psychiatric disorders. Here, we show that, in magnetic resonance imaging scans of a large sample of normal individuals, this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of variation in brain morphology related to learning and memory.
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