Genetic Linkage Localizes an Adolescent Idiopathic Scoliosis and Pectus Excavatum Gene to Chromosome 18 q

Abstract

Linkage analysis in this large family demonstrated a novel locus for AIS and PE on chromosome 18 q. Because of the increased frequency of PE in family members of AIS patients, consideration of family members with PE as affected may increase the power of AIS genetic linkage studies.