Phenyl-glycinol based NK1 receptor antagonists — towards the minimum pharmacophore

The synthesis of amino acid derivatives by catalytic phase-transfer alkylations

Martin O’Donnell, Thomas M. Eckrich · Tetrahedron Letters · 1978 · 108 citations

Natural Sciences, Chemistry, Medicinal Chemistry +10

Piperidine-ether based hNK1 antagonists 2: Investigation of the effect of N-substitution

Timothy Harrison, Andrew P. Owens, Brian J. Williams et al. · Bioorganic & Medicinal Chemistry Letters · 1995 · 32 citations

Pharmacy, Medicinal Chemistry, Pharmacology +9

Acyclic NK-1 antagonists: 2-benzhydryl-2-aminoethyl ethers

Brian J. Williams, Martin Teall, Jeffrey Mc Kenna et al. · Bioorganic & Medicinal Chemistry Letters · 1994 · 28 citations

Medicine, Medicinal Chemistry, Pharmacology +5

Quinuclidine-based NK-1 antagonists I: 3-benzyloxy-1-azabicyclo[2.2.2]octanes

Eileen M. Seward, Christopher J. Swain, Kevin J. Merchant et al. · Bioorganic & Medicinal Chemistry Letters · 1993 · 28 citations

Medicine, Medicinal Chemistry, Pharmacology +7

Rational design of high affinity tachykinin NK2 receptor antagonists

S. Boyle, Steven Guard, Julie Hodgson et al. · Bioorganic & Medicinal Chemistry · 1994 · 27 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12