The gene, MIC4, which controls expression of the antigen defined by monoclonal antibody F10.44.2, is on human chromosome 11

Abstract

The monoclonal antibody, F10.44.2, is directed against a human antigenic determinant of restricted tissue distribution. In this report it is shown that this determinant is coded for by a gene, MIC4, which is on human chromosome 11, as shown by its reactivity with a panel of somatic cell hybrids. Synteny with an antigen recognized by another monoclonal antibody, W6/34, is demonstrated by hybrid and fluorescence-activated cell sorter analysis, although it is clear from absorption analysis that the determinants involved are on different molecules.