Contribution of CYP3A4, CYP2B6, and CYP2C9 Isoforms to N-Demethylation of Ketamine in Human Liver Microsomes

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

Tsutomu Shimada, Hiroshi Yamazaki, Mayumi Mimura et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 2.8K citations

Medicine, Biochemistry, Pharmacology +15

Ketamine—Its Pharmacology and Therapeutic Uses

Paul F. White, Walter L. Way, Anthony J. Trevor · Anesthesiology · 1982 · 1.5K citations · Full text

Medicine, Pharmacology, Pharmacotherapy +16

Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver.

Thomas Lang, Kathrin Klein, Joachim E. Fischer et al. · Pharmacogenetics · 2001 · 569 citations

Medicine, Genetics, Molecular Genetics +17

Cytochrome P450 isoform inhibitors as a tool for the investigation of metabolic reactions catalyzed by human liver microsomes.

Martine Bourrié, Viviane Meunier, Yves Berger et al. · Journal of Pharmacology and Experimental Therapeutics · 1996 · 362 citations

Medicine, Biochemistry, Pharmacology +15

Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9

Sandra Baldwin, J. C. Bloomer, Graeme Smith et al. · Xenobiotica · 1995 · 298 citations

Medicine, Biochemistry, Pharmacology +17