Acta Crystallographica Section D Biological Crystallography · 1996 · 14 citations · 0 references
Life SciencesBiochemistryBioinformaticsProtein BiochemistryStructural BioinformaticsStructural BiologyCrystallographyMacromolecular Structure DeterminationProtein Sequence AnalysisProtein StructureStructural RefinementX-ray CrystallographyElectron Density Map InterpretationElectron Density MappingMacromolecular CrystallographyMatchingProtein CrystallographyProtein Structure AnalysisProtein Structure DeterminationProtein Structure Matching
The matching of the known polypeptide sequence to the electron density is a critical step in solving protein structures by the crystallographic method. Tools have been developed to help in defining the placement of the sequence, both qualitatively and quantitatively. They have been tested with good results on two proteins whose structures were solved by the MIR method.