Concepedia

Thalidomide suppresses inflammation in adenine-induced CKD with uraemia in mice

Alexandre Chagas Santana, Sabrina Degaspari, Sérgio Catanozi, Humberto Dellê, Larissa de Sá Lima, Cleonice Silva, Paula Blanco, Kim Solez, Cristóforo Scavone, Irene L. Noronha

Nephrology Dialysis Transplantation · 2013 · 75 citations · 33 references

DOIFull text

Open access

Abstract

Dietary adenine caused advanced CKD with uraemia in mice providing a useful experimental model to study molecular and morphological changes associated with this disease. The negative impact of inflammation in this CKD model was overcome by the marked anti-inflammatory effects of thalidomide, promoting renal protection.

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