FEBS Letters · 2003 · 51 citations · 15 references
Life SciencesGeneticsMolecular BiologyDna RepairDna ReplicationEnzymologyDna Double-strand Break RepairDna Polymerase FunctionDna Repair In PlantsDna Strand BreaksRibosome FunctionRna Polymerase FunctionDna Repair MechanismsDna Strand Break RepairPoly(adp-ribose) Polymerase ActivityPoly(adp-ribose) Polymerase-mediated RepairRibonucleotide RemovalRrna Modification
It has been known that ribosome-inactivating proteins (RIPs) from plants damage ribosomes by removing adenine from a precise position of rRNA. Subsequently it was observed that all tested RIPs depurinate DNA, and some of them also non-ribosomal RNAs and poly(A), hence the denomination of adenine polynucleotide glycosylases was proposed. We report now that ricin, saporin-L2, saporin-S6, gelonin and momordin depurinate also poly(ADP-ribosyl)ated poly(ADP-ribose) polymerase (auto modified enzyme), an enzyme involved in DNA repair. We observed also that all RIPs but gelonin induce transformation of fibroblasts, possibly as a consequence of damage to DNA and of the altered DNA repair system.
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Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions
Damien D’Amours, Serge Desnoyers, Icy D’Silva et al. · Biochemical Journal · 1999 · 1.8K citations · Full text