Concepedia

Gene delivery with low molecular weight linear polyethylenimines

Miriam Breunig, Uta Lungwitz, Renate Liebl, Claudia Fontanari, Juergen Klar, Armin Kurtz, Torsten Blunk, Achim Goepferich

The Journal of Gene Medicine · 2005 · 121 citations · 33 references

DOI

Abstract

Our study suggests that LPEIs with low MWs are promising candidates for non-viral gene delivery, because they are more efficient and substantially less toxic than their higher MW counterparts.

References

33

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.

Otmane Boussif, Frank Lezoualc’h, Maria Antonietta Zanta et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations · Full text

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Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells.

Emma Jean Bowman, Annette Siebers, Karlheinz Altendorf · Proceedings of the National Academy of Sciences · 1988 · 1.8K citations · Full text

, , +17

Chloride Accumulation and Swelling in Endosomes Enhances DNA Transfer by Polyamine-DNA Polyplexes

N.D. Sonawane, Francis C. Szoka, A.S. Verkman · Journal of Biological Chemistry · 2003 · 1.1K citations · Full text

Size matters: Molecular weight affects the efficiency of poly(ethylenimine) as a gene delivery vehicle

W.T. Godbey, Kenneth K. Wu, Antonios G. Mikos · Journal of Biomedical Materials Research · 1999 · 817 citations

Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine

Klaus Kunath · Journal of Controlled Release · 2003 · 797 citations

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