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Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights

Ulrich Grädler, Thomas Fuchß, Wolf‐Rüdiger Ulrich, Rainer Boer, Andreas Strub, Christian Heßlinger, Céline Anézo, Kay Diederichs, Andrea Zaliani

Bioorganic & Medicinal Chemistry Letters · 2011 · 34 citations · 28 references

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28

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

David A. Geller, Charles J. Lowenstein, Richard A. Shapiro et al. · Proceedings of the National Academy of Sciences · 1993 · 833 citations

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Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle

Masaki Nakane, Harald Schmidt, Jennifer S. Pollock et al. · FEBS Letters · 1993 · 548 citations · Full text

, , +10

Molecular cloning and characterization of human endothelial nitric oxide synthase

Philip A. Marsden, Keith Schappert, Hai Sheine Chen et al. · FEBS Letters · 1992 · 492 citations · Full text

, , +11

Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation.

Thierry Fischmann, Alan Hruza, Xiao Da Niu et al. · Nature Structural Biology · 1999 · 456 citations

, , +10

The Structure of Nitric Oxide Synthase Oxygenase Domain and Inhibitor Complexes

Brian R. Crane, A.S. Arvai, Ratan Gachhui et al. · Science · 1997 · 347 citations

, , +17