Concepedia

Total Synthesis of Reblastatin

Iwona Wrona, Ana E. Gabarda, Gwilherm Evano, James S. Panek

Journal of the American Chemical Society · 2005 · 73 citations · 22 references

DOI

Concepts

Abstract

Enantioselective total synthesis of reblastatin is described. The synthesis highlights hydrozirconation, transmetalation, aldehyde addition sequence to install E-trisubstituted olefin and C7 stereocenter, and the first use of an intramolecular Buchwald-like amidation reaction to close the 19-membered macrolactam.

References

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