Phosporamidon inhibits the vasoconstrictor effects evoked by big endothelin-1 but not the elevation of plasma endothelin-1 in vivo

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

Masashi Yanagisawa, Hiroki Kurihara, Sadao Kimura et al. · Nature · 1988 · 10.8K citations · Full text

Life Sciences, Cell Biology, Physiology +9

Integrated cardiac, renal, and endocrine actions of endothelin.

W L Miller, M REDFIELD, John C. Burnett · Journal of Clinical Investigation · 1989 · 475 citations · Full text

Medicine, Pharmacology, Physiology +17

The hydrolysis of endothelins by neutral endopeptidase 24.11 (enkephalinase).

Jayanthi Vijayaraghavan, A G Scicli, O. A. Carretero et al. · Journal of Biological Chemistry · 1990 · 245 citations · Full text

Life Sciences, Biochemistry, Physiology +8

Friedman and Quade tests: BASIC computer program to perform nonparametric two-way analysis of variance and multiple comparisons on ranks of several related samples

Computers in Biology and Medicine · 1987 · 235 citations

Natural Sciences, Biostatistics, Experimental Design +8

Conversion of Big Endothelin-1 to 21-Residue Endothelin-1 Is Essential for Expression of Full Vasoconstrictor Activity

Sadao Kimura, Yoshitoshi Kasuya, Tatsuya Sawamura et al. · Journal of Cardiovascular Pharmacology · 1989 · 184 citations

Life Sciences, Biochemistry, Physiology +9