TIPE2, a Negative Regulator of Innate and Adaptive Immunity that Maintains Immune Homeostasis

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Estelle Bettelli, Yijun Carrier, Wenda Gao et al. · Nature · 2006 · 6.9K citations

Life Sciences, Developmental Biology, Immunology +16

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

Douglas A. Rubinson, Christopher P. Dillon, Adam V. Kwiatkowski et al. · Nature Genetics · 2003 · 1.5K citations

Life Sciences, Genetics, Molecular Biology +17

Myelin Oligodendrocyte Glycoprotein–specific T Cell Receptor Transgenic Mice Develop Spontaneous Autoimmune Optic Neuritis

Estelle Bettelli, Maria Pagany, Howard L. Weiner et al. · The Journal of Experimental Medicine · 2003 · 821 citations · Full text

Life Sciences, Immunology, Neuroscience +17

Efficient and Rapid Induction of a Chronic Myelogenous Leukemia-Like Myeloproliferative Disease in Mice Receiving P210 bcr/abl-Transduced Bone Marrow

Warren S. Pear, Juli P. Miller, Lanwei Xu et al. · Blood · 1998 · 738 citations

Medicine, Hematology, Oncology +12

Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

Hyung J. Chun, Lixin Zheng, Manzoor Ahmad et al. · Nature · 2002 · 692 citations

Life Sciences, Immunology, Molecular Genetics +16