Concepedia

Application of supercritical fluid extraction and supercritical fluid chromatography to the production of taxanes as anti‐cancer drugs

Darren M. Heaton, Keith D. Bartle, Christopher M. Rayner, Anthony A. Clifford

Journal of High Resolution Chromatography · 1993 · 24 citations · 10 references

DOI

Concepts

Abstract

Abstract The supercritical fluid extraction (SFE) of taxicin from the dried needles of the English yew tree, Taxus baccata is described. Analysis by supercritical fluid chromatography (SFC) and proton NMR spectroscopy was used to confirm identity and purity. The extraction efficiency of SFE is comparable with that obtained using liquid solvents. Such taxanes may be used semi‐synthetically to prepare potential anti‐cancer drugs.

References

10

Plant antitumor agents. VI. Isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia

M. C. Wani, Harold L. Taylor, Monroe E. Wall et al. · Journal of the American Chemical Society · 1971 · 4.1K citations

, , +10

A model for dynamic extraction using a supercritical fluid

Keith D. Bartle, Anthony A. Clifford, Steven B. Hawthorne et al. · The Journal of Supercritical Fluids · 1990 · 200 citations

, , +11

Taxol Content in Bark, Wood, Root, Leaf, Twig, and Seedling from Several Taxus Species

N. Vidensek, Phaik‐Eem Lim, Amy M. Campbell et al. · Journal of Natural Products · 1990 · 172 citations

, , +8

Cell Culture of Taxus as a Source of the Antineoplastic Drug Taxol and Related Taxanes

Arthur Germano Fett‐Neto, Frank DiCosmo, William F. Reynolds et al. · Nature Biotechnology · 1992 · 138 citations

, , +12

[3.3] Sigmatropy within 1-vinyl-2-alkenyl-7,7-dimethyl-exo-norbornan-2-ols. The first atropselective oxyanionic Cope rearrangement

Leo A. Paquette, Neil Pegg, Dana S. Toops et al. · Journal of the American Chemical Society · 1990 · 60 citations

, , +7