Acta Medica Scandinavica · 1969 · 30 citations · 24 references
PharmacyPharmacologyPharmacotherapyCardiovascular PharmacotherapyClinical PharmacologyPharmacodynamicsBlood Pressure ManagementDiuretic TherapyHemodynamic PharmacologyHypertension ManagementHypertension PharmacotherapySodium HomeostasisAntihypertensive Drug TherapyAntihypertensive PharmacologyBlood Volume AssessmentExchangeable Sodium EffectsExchangeable Sodium EstimationExchangeable Sodium MeasurementHemodynamic Drug EffectsPharmacological Interaction In Hypertension
Abstract Antipressor treatment with guanethidine for 8 to 14 days produce a significant average increase in blood volume and exchangeable sodium of 382 ml (8.5%) and 210 mEq (7%), respectively. Subsequent supplementary treatment with hydrochlorothiazide resulted in a normalization of the above‐mentioned parameters both during short‐term and long‐term management. It is proposed that these effects are of importance for the continued hypotensive effect of the thiazides.
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Hemodynamic and Hypotensive Effects of Long-term Therapy with Chlorothiazide
James Conway, P Lauwers · Circulation · 1960 · 255 citations · Full text